The relationship between BMD and you will pounds was more powerful than anywhere between Bmi and you may BMD
step three.step 3. Exposure Situations
Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).
One another Bmi and you can lbs was synchronised which have BMD, and you can BMC evidence as well as the strongest Pearson’s relationship coefficients have been located between weight and BMC as a whole stylish and you may trochanter places and you can new weakest of those was anywhere between Body mass index and you can femoral neck BMC. Brand new correlations anywhere between decades and you will BMD and BMC indicators had been bad (Table cuatro).
Age-modified proportion away from BMD and you can BMC adaptation told me from the Body mass index and you may lbs was shown in Desk 5. Lbs tended to inform you greater variations in BMD and you will BMC shipments whatsoever the fresh new learnt skeletal internet compared to the Bmi. It was shown from the steeper hill (?) of the respective linear regression contours. The best difference in BMD and you may BMC shipment searched at the trochanter BMC with lumbar BMC having weight. Lbs is an important predictor from BMD and BMC version when you look at the older Iranian guys.
cuatro. Dialogue
In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.
The components where fatty tissue exerts positive effects on the BMD status commonly completely clear. The newest putative procedure value out-of fat for skeletal ethics most likely stays in new character of a lot adipokines in the limbs remodeling courtesy affect one another formation and you may resorption. Has just, bones could have been noticed an enthusiastic endocrine body organ impacting fat control and you will sugar homoeostasis from procedures from bone-derived circumstances for example osteocalcin and you can osteopontin [23, 34–36]. Brand new putative crosstalk anywhere between body weight and skeleton constitutes a great homoeostatic viewpoints system www.datingranking.net/nl/connexion-overzicht in which adipokines and you may molecules released by osteoblasts and you can osteoclasts portray the link away from an energetic bone-adipose axis [34–36]. Obesity is also on the BMD from the conversion process away from androgen to the hormone estrogen , and therefore advances bones size both in visitors [38, 39] and you will keeps match plasma degrees of insulin and controlling issues together with insulin-like progress grounds-step 1, leptin, and adiponectin . While doing so, carrying excess fat will bring padding towards the stylish in case there are a slip . Although not, the new elements which a few of these occurrences exists will still be unsure.
