I am not saying believing that the label diligently reflects this new contents of the brand new report

I am not saying believing that the label diligently reflects this new contents of the brand new report

Authors’ response

What’s the method for defining punctual-changing and you will slow-changing healthy protein-programming family genes? If for example the system is simply “Play with Ka”, I might believe people have over you to definitely prior to.

Authors’ impulse

You will find altered brand new term so you’re able to “Nonsynonymous replacing rate (Ka) was a relatively uniform parameter to have determining timely-changing and you can sluggish-changing healthy protein-programming genes”. I have checked this new relevant literary works very carefully and just have maybe not located publications which have complete such as comprehensive ratings on steps.

Recommendations

Lander Es, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, et al: 1st sequencing and you will study of your human genome. Nature. 2001 Senior Sites dating online, 409: 860-921. 7062.

Demuth JP, De- Bie T, Stajich JE, Cristianini Letter, Hahn MW: The latest progression away from mammalian gene family members. PLoS One. 2006, 1: e85-/record.pone.0000085.

Williamson SH, Hubisz MJ, Clark AG, Payseur BA, Bustamante Computer game, Nielsen R: Localizing latest adaptive advancement on the peoples genome. PLoS Genet. 2007, 3: e90-/journal.pgen.0030090.

Bustamante Computer game, Fledel-Alon A great, Williamson S, Nielsen Roentgen, Hubisz MT, Glanowski S, Tanenbaum DM, Light TJ, Sninsky JJ, Hernandez RD, Civello D, Adams MD, Cargill M, Clark AG: Pure possibilities into healthy protein-programming genes on the people genome. Nature. 2005, 437: 1153-1157. /nature04240.

Nielsen R, Bustamante C, Clark AG, Glanowski S, Sackton TB, Hubisz MJ, Fledel-Alon Good, Tanenbaum DM, Civello D, Light TJ, J Sninsky J, Adams MD, Cargill Meters: A browse for surely chosen family genes about genomes away from people and you can chimpanzees. PLoS Biol. 2005, 3: e170-/log.pbio.0030170.

Kosiol C, Vinar T, da Fonseca RR, Hubisz MJ, Bustamante Computer game, Nielsen R, Siepel An excellent: Patterns out of confident choices inside six Mammalian genomes. PLoS Genet. 2008, 4: e1000144-/diary.pgen.1000144.

Clark AG, Glanowski S, Nielsen Roentgen, Thomas PD, Kejariwal A great, Todd MA, Tanenbaum DM, Civello D, Lu F, Murphy B, Ferriera S, Wang Grams, Zheng X, Light TJ, Sninsky JJ, Adams MD, Cargill M: Inferring nonneutral development off human-chimp-mouse orthologous gene trios. Research. 2003, 302: 1960-1963. /research.1088821.

Locke DP, Hillier LW, Warren Rest room, Worley KC, Nazareth LV, Muzny DM, Yang SP, Wang Z, Chinwalla From the, Minx P, ainsi que al: Comparative and you may group study from orang-utan genomes. Characteristics. 2011, 469: 529-533. /nature09687.

Gibbs RA, Rogers J, Katze Mg, Bumgarner R, Weinstock GM, Mardis Emergency room, Remington KA, Strausberg RL, Venter JC, Wilson RK, ainsi que al: Evolutionary and you will biomedical skills regarding the rhesus macaque genome. Research. 2007, 316: 222-234. /science.1139247.

Go CM, Giulotto E, Sigurdsson S, Zoli Meters, Gnerre S, Imsland F, Lear TL, Adelson DL, Bailey E, Bellone RR, et al: Genome series, comparative research, and you may population genes of your own residential horse. Science. 2009, 326: 865-867. /research.1178158.

Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal Yards, Fasten Meters, Chang JL, Kulbokas EJ, Zody MC, mais aussi al: Genome succession, relative research and you may haplotype framework of one’s residential canine. Character. 2005, 438: 803-819. /nature04338.

Elsik CG, Tellam RL, Worley KC, Gibbs RA, Muzny DM, Weinstock GM, Adelson DL, Eichler EE, Elnitski L, Guigo Roentgen, et al: The fresh genome sequence of taurine cattle: a windows so you’re able to ruminant biology and you will evolution. Science. 2009, 324: 522-528. /technology.1169588.

Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Agarwala R, Ainscough Roentgen, Alexandersson Meters, An enthusiastic P, ainsi que al: First sequencing and comparative studies of mouse genome. Character. 2002, 420: 520-562. /nature01262.

Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott Grams, Steffen D, Worley KC, Burch PE, mais aussi al: Genome succession of your Brown Norway rodent output understanding into mammalian evolution. Nature. 2004, 428: 493-521. /nature02426.

Mikkelsen TS, Wakefield MJ, Aken B, Amemiya CT, Chang JL, Duke S, Garber Meters, Gentles AJ, Goodstadt L, Heger An excellent, et al: Genome of your own marsupial Monodelphis domestica suggests when you look at the, 447: 167-177. /nature05805.